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Anticancer Agents from Natural Products (Hardcover, 2nd edition)
Loot Price: R6,618
Discovery Miles 66 180
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Anticancer Agents from Natural Products (Hardcover, 2nd edition)
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The approach to drug discovery from natural sources has yielded
many important new pharmaceuticals inaccessible by other routes. In
many cases the isolated natural product may not be an effective
drug for any of several reasons, but it nevertheless may become a
drug through chemical modification or have a novel pharmacophore
for future drug design. In summarizing the status of natural
products as cancer chemotherapeutics, Anticancer Agents from
Natural Products, Second Edition covers the: History of each
covered drug-a discussion of its mechanism on action, medicinal
chemistry, synthesis, and clinical applications Potential for novel
drug discovery through the use of genome mining as well as future
developments in anticancer drug discovery Important biosynthetic
approaches to "unnatural" natural products Anticancer Agents from
Natural Products, Second Edition discusses how complex
target-oriented synthesis-enabled by historic advances in
methodology-has enormously expanded the scope of the possible. This
book covers the current clinically used anticancer agents that are
either natural products or are clearly derived from natural product
leads. It also reviews drug candidates currently in clinical
development since many of these will be clinically used drugs in
the future. Examples include the drugs etoposide and teniposide
derived from the lead compound podophyllotoxin; numerous analogs
derived from taxol; topotecan, derived from camptothecin; and the
synthetic clinical candidates, E7389 and HTI-286, developed from
the marine leads, halichondrin B and hemiasterlin.
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