This book focusses on evolutionary, structural and functional
aspects of pore-forming proteins, bringing together prominent
researchers in the fields of structural biology and cellular and
biophysical techniques. The focus is on the MACPF/CDC protein super
family that was originally discovered because of unexpected
structural similarity between a domain present in bacterial
cholesterol-dependent cytolysins (CDC) and proteins of the membrane
attack complex/perforin (MACPF) family. Members of the MACPF/CDC
super family are crucial for many biological processes, being
efficient agents of development, defence, attack and invasion of
cells and tissues. However, their best-known role is in bacterial
pathogenesis and the proper functioning of the vertebrate immune
system, via formation of transmembrane pores in target cell
membranes. The book contains chapters on the distribution of
MACPF/CDC proteins and on aspects of their evolution and structural
properties, the similarities between different super family members
and functional properties of some of the best known examples. The
book also contains an overview of biophysical approaches that may
be used in the future to provide further insights into how these
interesting proteins function.
General
| Imprint: |
Springer
|
| Country of origin: |
Netherlands |
| Series: |
Subcellular Biochemistry, 80 |
| Release date: |
September 2016 |
| First published: |
2014 |
| Editors: |
Gregor Anderluh
• Robert Gilbert
|
| Dimensions: |
235 x 155 x 18mm (L x W x T) |
| Format: |
Paperback
|
| Pages: |
329 |
| Edition: |
Softcover reprint of the original 1st ed. 2014 |
| ISBN-13: |
978-9402403398 |
| Categories: |
Books
|
| LSN: |
9402403396 |
| Barcode: |
9789402403398 |
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