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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Arteriosclerosis - New Insights into Pathogenetic Mechanisms and Prevention (Paperback, Softcover reprint of the original 1st ed. 1994)
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Arteriosclerosis - New Insights into Pathogenetic Mechanisms and Prevention (Paperback, Softcover reprint of the original 1st ed. 1994)
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A vast literature has been concerned with arteriosclerosis and yet,
many aspects of pathogenesis and of the mechanism of development of
the arteriosclerotic vascular lesion remain only poorly understood.
In recent years, our knowledge of the earliest stages of
arteriosclerosis have greatly improved. By now, we have learned to
relate morphologic changes to disturbances in function. It has been
of particular impor tance that components of the arterial wall
could be analyzed in regard to dysfunction, for example, in the
endothelium or the vascular smooth muscle. The interaction of the
different morphological components of the vascular wall could thus
be much bet ter understood. Likewise, the interaction between the
arterial wall and the flowing blood could be much better described,
including the intimate relationship between platelets and the
endothelium, the coagulation system and the endothelium, the
granulocytes and the endothelial cell layer, as well as processes
of migration of blood cells into the subendothelial space. The
recognition of functional and morphological disturbance has
attained clinical significance not only because the
arteriosclerotic diseases have quantitatively reached the
dimensions of an epidemic, that is, of a magnitude never been
witnessed. It is also because of the development of new drugs that
interfere with the atherogenic process and thereby prevent the
development of the disease or halt its progression. It is also
becoming increasingly possible to inhibit the occurrence of
complications in existing arteriosclerotic lesions in manifest
disease, i. e.
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