The response of (laboratory) animals to anaesthetics and analgesics
shows intraspecies variability. Besides environmental influences,
genetic factors might be involved in this phenomenon. In the
studies described in this book, rabbit and rat inbred strains were
used to identify differences in response to anaesthetics and
analgesics. Parameters for a genetic analysis were thus provided to
identify candidate genes involved in this variability. Both in the
rat and rabbit,significant strain differences were observed in the
response to a variety of commonly used anaesthetics and analgesics
in (laboratory animal) medicine. The difference in response to
medetomidine between two rabbit strains was linked to differences
in the anaesthetic's biotransformation rate. This response was then
genetically analyzed and candidate genes were identified on the
rabbit genetic map. In the rats it was demonstrated that
buprenorphine administration did not only result in strain-specific
responses to its analgesic but also to its behavioural effects.
This book will aid medical and veterinary researchers in the
development of tailored anaesthesia.
General
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