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Expression of Tenascin in Ameloblastoma and Ameloblastic Fibroma (Paperback)
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Expression of Tenascin in Ameloblastoma and Ameloblastic Fibroma (Paperback)
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Odontogenic lesions range from developmental anomalies to benign
and malignant neoplasms. Ameloblastoma, known for its locally
invasive behaviour and high risk of recurrence, is a frequently
encountered benign ectodermal odontogenic tumour, while
ameloblastic fibroma is a mixed odontogenic tumour with relatively
lesser frequency. These tumors demonstrate varying inductive
interactions between odontogenic epithelium and odontogenic
ectomesenchyme of which extracellular matrix (ECM) plays an
important role. Tenascin, a large glycoprotein component of ECM is
involved in cell-to-cell and cell-ECM interactions. A diverse
expression of tenascin has been reported in various lesions, where
it may affect cellular proliferation, differentiation and
migration. Till to date, there are only a few reports on the role
played by tenascin in odontogenic tumors. The purpose of this study
was to analyze the expression and distribution of tenascin in
ameloblastoma and ameloblastic fibroma with varied stromal back
ground thus to understand their phenotypical behavior.
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