Parents have come to depend on vaccines to protect their children
from a variety of diseases. Some evidence suggests, however, that
vaccination against pertussis (whooping cough) and rubella (German
measles) is, in a small number of cases, associated with increased
risk of serious illness. This book examines the controversy over
the evidence and offers a comprehensively documented assessment of
the risk of illness following immunization with vaccines against
pertussis and rubella. Based on extensive review of the evidence
from epidemiologic studies, case histories, studies in animals, and
other sources of information, the book examines: The relation of
pertussis vaccines to a number of serious adverse events, including
encephalopathy and other central nervous system disorders, sudden
infant death syndrome, autism, Guillain-Barre syndrome, learning
disabilities, and Reye syndrome. The relation of rubella vaccines
to arthritis, various neuropathies, and thrombocytopenic purpura.
The volume, which includes a description of the committee's methods
for evaluating evidence and directions for future research, will be
important reading for public health officials, pediatricians,
researchers, and concerned parents. Table of Contents Front Matter
1 Executive Summary 2 Histories of Pertussis and Rubella Vaccines 3
Methodologic Considerations in Evaluating the Evidence 4 Evidence
Concerning Pertussis Vaccines and Central Nervous System Disorders,
Including Infantile Spasms, Hypsarrhythmia, Aseptic Meningitis, and
Encephalopathy 5 Evidence Concerning Pertussis Vaccinces and Deaths
Classified as Sudden Infant Death Syndrome (SIDS) 6 Evidence
Concerning Pertussis Vaccines and Other Illnesses and Conditions 7
Evidence Concerning Rubella Vaccines and Arthritis,
Radiculoneuritis, and Thrombocytopenic Purpura Afterword on
Research Needs Bibliography Glossary of Terms Appendix A:
Strategies for Gathering Information: Adverse Effects of Pertussis
and Rubella Vaccines Appendix B: Pertussis and Rubella Vaccines: A
Brief Chronology Appendix C: Animal Models for the Study of
Whooping Cough and the Testing of Vaccine Materials Appendix D:
Technical Details of Power Calculations and Meta-Analyses Appendix
E: Possible Involvement of Aluminum Salts in Erythema Multiforme,
Encephalopathy, or Other Adverse Events After Pertussis
Immunization Appendix F: Committee and Staff Biographies Index
General
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