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Improving the Efficiency and Effectiveness of Genomic Science Translation - Workshop Summary (Paperback)
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Improving the Efficiency and Effectiveness of Genomic Science Translation - Workshop Summary (Paperback)
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The process for translating basic science discoveries into clinical
applications has historically involved a linear and lengthy
progression from initial discovery to preclinical testing,
regulatory evaluation and approval, and, finally, use in clinical
practice. The low rate of translation from basic science to
clinical application has been a source of frustration for many
scientists, clinicians, investors, policy makers, and patients who
hoped that investments in research would result in improved
products and processes for patients. Some feel that the anticipated
deliverables from the Human Genome Project have not yet
materialized, and although understanding of human health and
disease biology has increased, there has not been a concomitant
increase in the number of approved drugs for patients over the past
10 years. Improving the Efficiency and Effectiveness of Genomic
Science Translation is the summary of a workshop convened by the
Institute of Medicine Roundtable on Translating Genomic-Based
Research for Health in December 2012 to explore ways to improve the
efficiency and effectiveness of the translation of genomic science
to clinical practice. The workshop convened academic researchers,
industry representatives, policy makers, and patient advocates to
explore obstacles to the translation of research findings to
clinical practice and to identify opportunities to support
improvement of the early stages of the process for translation of
genetic discoveries. This report discusses the realignment of
academic incentives, the detection of innovative ways to fund
translational research, and the generation or identification of
alternative models that accurately reflect human biology or disease
to provide opportunities to work across sectors to advance the
translation of genomic discoveries. Table of Contents Front Matter
1 Introduction 2 Connecting Basic Research and Health Care Needs 3
Moving Basic Science Forward 4 Industry and Venture Capital 5 Role
of Advocacy in Facilitating Translation of Basic Scientific
Research 6 Strategies for Change References Appendix A: Workshop
Agenda Appendix B: Speaker Biographical Sketches Appendix C:
Statement of Task Appendix D: Registered Attendees
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