Observational Studies in a Learning Health System - Workshop Summary (Paperback)

Clinical research strains to keep up with the rapid and iterative evolution of medical interventions, clinical practice innovation, and the increasing demand for information on the clinical effectiveness of these advancements. In response to the growing availability of archived and real-time digital health data and the opportunities this data provides for research, as well as the increasing number of studies using prospectively collected clinical data, the Institute of Medicine\'s Roundtable on Value & Science-Driven Health Care convened a workshop on Observational Studies in a Learning Health System. Participants, including experts from a wide range of disciplines - clinical researchers, statisticians, biostatisticians, epidemiologists, health care informaticians, health care analytics, research funders, health products industry, clinicians, payers, and regulators - explored leading edge approaches to observational studies, charted a course for the use of the growing health data utility, and identified opportunities to advance progress. Workshop speakers and individual participants strove to identify stakeholder needs and barriers to the broader application of observational studies. Observational Studies in a Learning Health Systemis the summary of the workshop. This report explores the role of observational studies in the generation of evidence to guide clinical and health policy decisions. The report discusses concepts of rigorous observational study design and analysis, emerging statistical methods, and opportunities and challenges of observational studies to complement evidence from experimental methods, treatment heterogeneity, and effectiveness estimates tailored toward individual patients. Table of Contents Front Matter 1 Introduction 2 Issues Overview for Observational Studies in Clinical Research 3 Engaging the Issue of Bias 4 Generalizing Randomized Clinical Trial Results to Broader Populations 5 Detecting Treatment-Effect Heterogeneity 6 Predicting Individual Responses 7 Strategies Going Forward 8 Common Themes for Progress Appendix A: Biographies of Workshop Speakers Appendix B: Workshop Agenda Appendix C: Workshop Participants

General

Imprint:	National Academies Press
Country of origin:	United States
Release date:	2014
First published:	2013
Authors:	Institute of Medicine • Roundtable on Value and Science-Driven Health Care • A Learning Health System Activity
Editors:	Joe Alper • Claudia Grossmann
Dimensions:	229 x 152 x 0mm (L x W x T)
Format:	Paperback
Pages:	134
ISBN-13:	978-0-309-29081-4
Categories:	Books > Medicine > General issues > Health systems & services > General
LSN:	0-309-29081-3
Barcode:	9780309290814

Is the information for this product incomplete, wrong or inappropriate? Let us know about it.

Does this product have an incorrect or missing image? Send us a new image.

Is this product missing categories? Add more categories.

Review This Product

No reviews yet - be the first to create one!