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Repair and Regeneration of the Nervous System - Report of the Dahlem Workshop on Repair and Regeneration of the Nervous Sytem Berlin 1981, November 29 - December 4 (Paperback, Softcover reprint of the original 1st ed. 1982)
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Repair and Regeneration of the Nervous System - Report of the Dahlem Workshop on Repair and Regeneration of the Nervous Sytem Berlin 1981, November 29 - December 4 (Paperback, Softcover reprint of the original 1st ed. 1982)
Series: Dahlem Workshop Report, 24
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5) To what extent do events occurring during regeneration re semble
those seen in development? Questions like these remain open,
particularly in relation to the mammalian central nervous system
and to the effects of lesions or disease. The first chapters of
this volume are concerned primarily with normal and abnormal
development of the nervous system. New concepts have emerged over
the past few years as a result of experiments made on the
development of the higher nervous system in mammals. Thus, the
principles of cell death, competition, selective retraction of
specific processes, and the effects of abnormalities on the
development of the rest of the system have now been extensively
investigated. In addition, considerable information is available
about biochemical changes during normal and abnormal development in
the human. At the other end of the scale, in invertebrates it is
now possible to follow cell lineage and to define the origin and
fate of a sin gle neuron of known function together with its
processes. While an understanding of development is clearly
important for studying basic mechanisms of repair and regeneration,
one cannot expect the processes to be identical or even comparable
in the two situations. For example, cell migration, guidance by
radial glial fibers, selective cell death, and the critical periods
for competition, sprouting, and retraction observed in the visual
system can hardly playa part in repair."
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