Fifteen years ago the field of oxygen free radicals was just
beginning to launch into a new area of importance in pathology.
Since then, oxygen free radicals have been implicated in a number
of disease processes, including atherosclerosis and chronic
inflammation. Measuring in vivo Oxidative Damage brings together
methods by leading experts in the field of oxidative damage and by
scientists from clinical biochemistry laboratories who have had
much experience with the practical problems of measuring oxidative
damage in vivo. Many of the authors are involved in national and
international quality assurance programmes and routinely establish
these assays in clinical research laboratories. The book is divided
into 5 parts:
* Chromatographic procedures
* Measurement of 8-oxo deoxyguanosine
* Cellular-based methods
* Molecular-based assays
* Antioxidant activity.
Each part is designed to help the clinical scientist evaluate the
best method for their particular problem in measuring oxidative
damage in vivo. The methods represented are the ones most commonly
used and are deemed robust and simple enough to apply to clinical
material. Measuring in vivo Oxidative Damage is an ideal practical
reference work for the clinical scientist and is a must for all
laboratories in hospitals and research institutions which are
actively involved in analytical work.
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