The completion of sequences for over one hundred microbial genomes,
with more than 200 additional projects now under way, has vastly
multiplied the potential avenues for research using genetic,
biochemical, and bioinformatics tools, and has created the new
field of functional genomics. These advances have laid the
foundation for understanding key principles applicable to human
genome research.
Microbial Functional Genomics, the first comprehensive treatment
of this subject, provides a much-needed synthesis of genome-wide
studies on gene networks and functions, as well as the use of
genomic data and technology in addressing a host of biological
problems. Topics covered include:
- Genomics: introduction, history, and current challenges and
scope
- Microbial diversity and evolution from a genomics
perspective
- Computational methods for genome annotation and functional
prediction of genes
- DNA microarray technology and its application to gene
expression data analysis, mutation analysis, and microbial
detection
- Mutagenesis as a genomic tool for studying gene function
- The functional genomics of model organisms, bacterial
pathogens, and environmentally significant microorganisms
- The impact of genomics on antimicrobial drug discovery and
toxicology
Microbial Functional Genomics represents a timely summary of the
principles, approaches, and applications at the forefront of this
exciting and rapidly progressing field.
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