Preclinical screening for drug-induced mitochondrial dysfunction
can predict toxicity and revolutionizedrug development
All too often, despite adherence to regulatory guidelines, a new
drug reaches the market and its toxicity is not discovered until
many patients have been exposed. In many cases, this unpredicted
toxicity is due to the drug's adverse effects on mitochondrial
function or replication. This reference presents technological
developments that facilitate preclinical drug evaluation for
potential mitochondrial toxicity, addressing the issue early in the
drug development process. With chapters contributed by leading
specialists in their areas, Drug-Induced Mitochondrial
Dysfunction:
Explains basic concepts so that non-specialists can understand
mitochondrial function
Discusses mitochondrial etiology of organ toxicity, covering the
liver, heart, and kidney, as well as the skeletal muscle, nervous
system, and lipoatrophy
Details methodologies and techniques used to assess mitochondria
function so researchers can address drug-induced mitochondrial
impairment in their own labs
Includes new models that detect drug-induced mitochondrial
impairment in short-duration studies typical of preclinical drug
evaluations
Features both in vitro and in vivo methods for analysis,
including practical screening approaches for drug discovery and
development
This is the authoritative reference on drug-induced
mitochondrial dysfunction for safety assessment professionals in
the pharmaceutical industry, including bench scientists and
managers, and for pharmacologists and toxicologists in both drug
and environmental health sciences.
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