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Comparative, Maternal, and Epidemiologic Aspects (Paperback, Softcover reprint of the original 1st ed. 1977)
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Comparative, Maternal, and Epidemiologic Aspects (Paperback, Softcover reprint of the original 1st ed. 1977)
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Modification of embryonic development by genetic differences in the
mother is a well-regcognized phemomenon, but little is known about
the genet ics of these maternal traits or the mechanisms by which
they act. To illustrate the genetic approach to the problem,
examples are given of how differences in embryonic response to a
teratogen can be partitioned into those resulting from differences
in embryonic genotype (including the possible role of X-linked
genes in producing reciprocal cross differences), maternal
genotype, and cytoplasmically transmitted factors. The advantages
and limitations of analysis by appropriate crosses, in utero
treatments, embryo transfers, and in vitro experiments are
illustrated. The numerous inbred strains of the mouse, with
well-documented physiology, the recently developed recombinant
inbred strains, and the existence of easily identified biochemical
marker genes offer at tractive opportunities, so far largely
unexploited, for causal analysis of mater nal effects on
teratological responses. VII. ADDENDUM Since this chapter was
written, several relevant papers have appeared. The strain
difference between AI] and C57BU6] mice in frequency of
cleft-palate response to cortisone was fitted to a model of
normally distributed log tolerance (Biddle and Fraser, 1976).
Genetic differences, both in maternal uterine environment and
embryonic response, can be represented in terms of their effect on
the median effective dose required for the cleft-palate re sponse.
The maternal effect of AI] dams relative to C57BU6] dams caused a
two-fold reduction in embryonic tolerance to cortisone-induced
cleft palate."
General
Imprint: |
Springer-Verlag New York
|
Country of origin: |
United States |
Release date: |
May 2013 |
First published: |
1977 |
Editors: |
James Wilson
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Dimensions: |
244 x 170 x 18mm (L x W x T) |
Format: |
Paperback
|
Pages: |
334 |
Edition: |
Softcover reprint of the original 1st ed. 1977 |
ISBN-13: |
978-1-4615-8938-9 |
Categories: |
Books >
Reference & Interdisciplinary >
Interdisciplinary studies >
General
|
LSN: |
1-4615-8938-X |
Barcode: |
9781461589389 |
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