This new volume of Methods in Enzymology continues the legacy of
this premier serial with quality chapters authored by leaders in
the field. This volume covers recent research and methods
development for changing the DNA sequence within the genomes of
cells and organisms. Focusing on enzymes that generate
double-strand breaks in DNA, the chapters describe use of molecular
tools to introduce or delete genetic information at specific sites
in the genomes of animal, plant and bacterial cells.
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