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Biobanking in the Stem Cell Era - A Technical and Operational Guide (Paperback)
Loot Price: R1,113
Discovery Miles 11 130
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Biobanking in the Stem Cell Era - A Technical and Operational Guide (Paperback)
Series: Colloquium Series on Stem Cell Biology
Expected to ship within 10 - 15 working days
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The study of mental health disorders and the genetics behind these
disorders can be greatly enhanced by the use of induced pluripotent
stem cells (iPSC). Since many mental health disorders develop after
puberty, the only way in which to study the genetic mechanism of
these diseases previously was through cellular surrogates, such as
blood or cultured fibroblasts. Having the ability to reprogram
adult cells to the pluripotent stage provides the capacity to study
the onset of these disorders during a culture model of neural
development and to include the impact of genetic risk factors and
potential environmental triggers. Working with the National
Institute of Mental Health (NIMH), the Rutgers Cell and DNA
Repository (RUCDR) has begun banking iPSC source cells and
converting those source cells into iPSC for distribution to the
scientific community. Although initial protocols were developed to
reprogram fibroblasts, the ability to reprogram blood cells has
several advantages including less invasive collection, less post
collection manipulation, and the large number of samples in
existing collections. Here, we provide detailed protocols for
reprogramming either fibroblasts with retroviral vectors or
cryopreserved lymphocytes with Sendai viral vectors. Our goal is to
support the discovery of effective treatments for mental health
disorders. Table of Contents: Acknowledgments / Introduction /
Appendix / General Protocols / References / Author Biographies
General
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