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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Yeast as a Tool in Cancer Research (Hardcover, 2007 ed.)
Loot Price: R5,946
Discovery Miles 59 460
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Yeast as a Tool in Cancer Research (Hardcover, 2007 ed.)
Expected to ship within 10 - 15 working days
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Leland H. Hartwell Director, Fred Hutchinson Cancer Research
Center, Nobel Laureate for Medicine, 2001 Yeast has proved to be
the most useful single-celled organism for studying the fundamental
aspects of cell biology. Resources are now available for yeast that
greatly simplify and empower new investigations, like the presence
of strains with each gene deleted, each protein tagged and
databases on protein-protein interactions, gene regulation, and
subcellular protein location. A powerful combination of genetics,
cell biology, and biochemistry employed by thousands of yeast
researchers has unraveled the complexities of numerous cellular
processes from mitosis to secretion and even uncovered new insights
into prion diseases and the role of prions in normal biology. These
insights have proven, time and again, to foretell the roles of
proteins and pathways in human cells. The collection of articles in
this volume explores the use of yeast in pathway analysis and drug
discovery. Yeast has, of course, supplied mankind's most ubiquitous
drug for thousands of years. In one aspect, the role of yeast in
drug discovery is much like the role of yeast in other areas of
biology. Yeast offers the power of genetics and a repetoire of
resources available in no other organism. Using yeast in the study
of drug targets and metabolism can help to make a science of what
has been largely an empirical activity. A science of drug discovery
would permit rigorous answers to important questions.
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