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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Mitochondria and Their Role in Cardiovascular Disease (Paperback, 2013 ed.)
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Mitochondria and Their Role in Cardiovascular Disease (Paperback, 2013 ed.)
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Over the past two decades, due to dramatic advances in molecular
and cell biology, biochemistry, and genetics, our view on
mitochondria as a relatively static cellular powerhouse has changed
radically. We now know that these organelles play a critical role
in the normal and in the damaged heart. Written by Dr. Jose
Marin-Garcia, Director of the Molecular Cardiology and
Neuromuscular Institute, Mitochondria and Their Role in
Cardiovascular Disease brings readers up- to-date on the many
significant advances in the field of mitochondrial cardiovascular
medicine. The book begins with a general introduction to
mitochondria, followed by laboratory methods to study the structure
and function of the organelle, regulation of replication and
biogenesis, and the mechanisms and functional consequences of
mitophagia and mitochondrial dynamics. Subsequent chapters deal
with mitochondrial oxidative stress and the role that the organelle
plays in cell signaling and cell death. Discussions will be
undertaken on the biochemistry of mitochondrial cell signaling,
including the nature of the proteins engaged in these processes,
many of them only recently discovered. Later chapters examine the
role of mitochondria and mitochondrial abnormalities in
cardiovascular diseases, including their diagnosis, therapeutic
options currently available, animal models of mitochondrial
disease, and new frontiers in mitochondria cardiovascular medicine,
including areas of research that are relatively new or developing,
such as proteomics, next generation sequencing, and systems
biology.
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