Signal transduction pathways are at the core of most biological
processes and are critical regulators of heart physiology and
pathophysiology. The heart is both a transmitter and dynamic
receptor of a variety of intracellular and extracellular stimuli,
playing a critical role of an integrator of diverse signaling
mechanisms. Alterations in signaling pathways are contributing
factors in the development and progression of a broad spectrum of
diseases, ranging from dysrhythmias and atherosclerosis to
hypertension and the metabolic syndrome. Targeting specific
components of these signaling pathways has been shown to be
effective in preclinical studies with significant therapeutic
impact. This book brings together current knowledge in
cardiovascular cell signal transduction mechanisms, advances in
novel therapeutic approaches to improve cardiac function, and
discussion of future directions. Presented from a post-genomic
perspective, this exciting book introduces important new ideas in
cardiovascular systems biology. It is an invaluable reference for
cardiology researchers and practitioners.
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