Comprehensive overview of different aspects of autophagy as it
relates to neurodegenerative diseases. The pathogenesis of the main
neurodegenerative disorders includes either the accumulation of
altered or misfolded proteins or exposure to several toxics.
Autophagy constitute one of the two principal cellular pathways
implicate in the clearance of these material and can serve as a
neuroprotective mechanism. Topics include: the role of autophagy in
the brain, the role of autophagy in the principal neurodegenerative
disorders, and the mechanism by which different molecules cause
neurotoxicity and the role autophagy plays.
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