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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Multi-Drug Resistance in Cancer (Paperback, 2010 ed.)
Loot Price: R4,675
Discovery Miles 46 750
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Multi-Drug Resistance in Cancer (Paperback, 2010 ed.)
Series: Methods in Molecular Biology, 596
Expected to ship within 10 - 15 working days
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Chemotherapy is one of the major treatment options for cancer
patients; however, the efficacy of chemotherapeutic management of
cancer is severely limited by multidrug resistance, in that cancer
cells become simultaneously resistant to many structurally and
mechanistically unrelated drugs. In the past three decades, a
number of mechanisms by which cancer cells acquire multidrug
resistance have been discovered. In addition, the development of
agents or strategies to overcome resistance has been the subject of
intense study. This book contains comprehensive and up-to-date
reviews of multidrug resistance mechanisms, from over-expression of
ATP-binding cassette drug transporters such as P-glycoprotein,
multidrug resistance-associated proteins, and breast cancer
resistance p- tein to the drug ratio-dependent antagonism and the
paradigm of cancer stem cells. The book also includes strategies to
overcome multidrug resistance, from the development of compounds
that inhibit drug transporter function to the modulation of
transporter expression. In addition, this book contains techniques
for the detection and imaging of drug transporters, methods for the
investigation of drug resistance in animal models, and strategies
to evaluate the efficacy of resistance reversal agents. The book
intends to provide a state-of-the-art collection of reviews and
methods for both basic and clinician investigators who are
interested in cancer multidrug resistance mechanisms and reversal
strategies. Tianjin, China Jun Zhou v Contents Preface. . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . v Contributors. . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . ix 1 Multidrug Resistance in Cancer
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . 1 Bruce C. Baguley 2 Multidrug Resistance in Oncology and
Beyond: From Imaging of Drug Efflux Pumps to Cellular Drug Targets
. . . . . . . . . . . . . . . . . . . . . . . . . .
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