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Mechanisms of Platelet Activation and Control (Paperback, Softcover reprint of the original 1st ed. 1993)
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Mechanisms of Platelet Activation and Control (Paperback, Softcover reprint of the original 1st ed. 1993)
Series: Advances in Experimental Medicine and Biology, 344
Expected to ship within 10 - 15 working days
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Recent years have seen tremendous advances in our understanding of
the molecular mechanism of platelet activation. All aspects of
signal transduction in platelets from the identification of surface
receptors, G proteins, phospholipases, protein kinases and
phosphatases, intracellular receptors for inositol phosphates, the
Ca2+ regulatory machinery, cytoskeletal constituents to the control
mechanism employing cyclic nucleotides has seen an explosion of
information regarding their importance and for each constituent in
the family of molecules to which they belong. This information has
been of interest to researchers across a wide spectrum of
disciplines including biochemists, pharmacologists, cell biologists
and clinicians. In April 1992 an International Symposium bearing
the name of this volume was organised at the Thrombosis Research
Institute to bring together scientists from across the world whose
common interest was the study of platelet activation and its
regulation. We were particularly encouraged by the positive
response from our speakers and the participants, their detailed
contributions and the very lively discussions that took place
throughout the two days of the symposium. Almost every aspect of
signal transduction in human platelets was represented. Of the
invited speakers twelve were from Europe (including the U. K. ),
eight from North America and one from Japan. This volume is a
compilation of chapters submitted by the speakers and represents a
concise but informative picture of the present knowledge of the
mechanisms of platelet activation and control.
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