Targeting the Wnt Pathway in Cancer (Paperback, 2011 ed.)

Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Release date:	October 2014
First published:	2011
Editors:	Kathleen H. Goss • Michael Kahn
Dimensions:	235 x 155 x 13mm (L x W x T)
Format:	Paperback
Pages:	240
Edition:	2011 ed.
ISBN-13:	978-1-4899-8164-6
Categories:	Books > Medicine > Other branches of medicine > Pharmacology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	1-4899-8164-0
Barcode:	9781489981646

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