Periodontitis is a disease characterized by loss of connective
tissue attachment and bone around the teeth in conjunction with the
formation of periodontal pockets due to the apical migration of the
junctional epithelium. Early diagnosis and treatment of progressive
periodontitis is important because of the irreversible nature of
this disease. Clinical measurements used in diagnosis of
periodontal diseases are often of limited usefulness in that they
are indications of previous periodontal disease rather than the
present disease activity. Diagnostic biomarkers in oral fluids like
saliva and gingival crevicular fluid (GCF) are highly beneficial in
the determination of current periodontal status. These substances
known as biomarkers help in determination of inflammatory mediator
levels.
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