Risedronate Effects on Bone Metastasis of Rat Mammary Tumor Cell Lines (Paperback)

When compared to MTA cells, MTB-01 cells were susceptible to risedronateinduced apoptosis, had decreased ability to bind to risedronate-treated bone, and did not produce MMP-2 or MMP-9 proteases. MTA cells were less susceptible to risedronateinduced apoptosis and produced MMP-2. Additionally, adhesion of MTA cells to bone matrix was not diminished by risedronate treatment. Our results suggest that the nonresponsive nature of the MTA cell line may be due to MMP-2 production (possibly allowing ongoing destruction of risedronate-treated bone), continued adhesion to risedronate-treated bone matrix, and decreased susceptibility to risedronate-induced apoptosis.

General

Imprint:	Lap Lambert Academic Publishing
Country of origin:	Germany
Release date:	February 2012
First published:	February 2012
Authors:	Kelli Boyd • Gregory Hall • Elizabeth Howerth
Dimensions:	229 x 152 x 8mm (L x W x T)
Format:	Paperback - Trade
Pages:	128
ISBN-13:	978-3-8473-4152-9
Categories:	Books > Professional & Technical > Veterinary science > General
LSN:	3-8473-4152-9
Barcode:	9783847341529

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