The study demonstrated the possibility of significantly improving
the dissolution performance of MX by simultaneous complexation with
cyclodextrin. The importance of proper selection of the most
suitable counter ion to adequately improve the cyclodextrin -
complexation efficiency has been pointed out. PVP showed a
synergistic effect when used in combination with HP -CD. Phase
solubility experiments demonstrated that the ternary system with
PVP (pH 5.8) exhibited a stability constant 12.9 times greater than
the binary complex. The drug solubility in the presence of 50mM HP
-CD was about 6.23 times higher than that in the binary system.
Results confirmed that the strong increase in the drug solubility
shown by HP -CD ternary system with PVP. Solid state demonstrated
that freeze drying technique was suitable for obtaining solid
homogeneous equimolar MX-HP -CD-PVP complexes. These systems could
be useful for formulating fast-dissolving drug solid dosage form
able to assure rapid onset of analgesic action and improved
bioavailability."
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