This is the first comprehensive guide to the design of behavioral
randomized clinical trials (RCT) for chronic diseases. It includes
the scientific foundations for behavioral trial methods, problems
that have been encountered in past behavioral trials, advances in
design that have evolved, and promising trends and opportunities
for the future. The value of this book lies in its potential to
foster an ability to "speak the language of medicine" through the
conduct of high-quality behavioral clinical trials that match the
rigor commonly seen in double-blind drug trials. It is relevant for
testing any treatment aimed at improving a behavioral, social,
psychosocial, environmental, or policy-level risk factor for a
chronic disease including, for example, obesity, sedentary
behavior, adherence to treatment, psychosocial stress, food
deserts, and fragmented care. Outcomes of interest are those that
are of clinical significance in the treatment of chronic diseases,
including standard risk factors such as cholesterol, blood
pressure, and glucose, and clinical outcomes such as
hospitalizations, functional limitations, excess morbidity, quality
of life, and mortality. This link between behavior and chronic
disease requires innovative clinical trial methods not only from
the behavioral sciences but also from medicine, epidemiology, and
biostatistics. This integration does not exist in any current book,
or in any training program, in either the behavioral sciences or
medicine.
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