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Secretin, Cholecystokinin, Pancreozymin and Gastrin (Paperback, Softcover reprint of the original 1st ed. 1973)
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Secretin, Cholecystokinin, Pancreozymin and Gastrin (Paperback, Softcover reprint of the original 1st ed. 1973)
Series: Handbook of Experimental Pharmacology, 34
Expected to ship within 10 - 15 working days
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In the beginning of this century physiology witnessed the creation
of a new concept, the hormonal regulation of the work of the
digestive organs. It was found that such essential functions as the
flow of pancreatic juice and emptying of bile into the intestine
were regulated by two hormones, secretin and cholecystokinin,
respectively. Already in 1925 French authors attempted to measure
the functional capacity of the exocrine pancreas by means of
stimulation with secretin. The use fulness of the secretin test in
this connection was definitely established by Scandinavian workers
in the 1930's. In spite of the difficulties in obtaining secretin
American authors succeeded in keeping the interest in the secretin
test alive. The development in the 1950's of counter-current, ion
exchange and chromato graphic techniques offered new possibilities
in this field. The intestinal hormones were known to be relatively
low molecular peptides and these could now be isolated in pure
form. Thus secretin was isolated in 1961, and cholecystokinin in
1964. The newly developed methods for peptide analysis likewise
soon brought us full information about the primary structure of the
peptides. Gastrin, the specific stimulant of the gastric acid
secretion, which was discovered in 1905 and acknowledged as a
hormone in 1938, was the first of the gastrointestinal hormones for
which the structure became known. This was in 1964. Synthesis soon
followed. These developments are reviewed in the first chapter of
the present volume."
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