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Immunologic Defects in Laboratory Animals 1 (Paperback, Softcover reprint of the original 1st ed. 1981)
Loot Price: R2,842
Discovery Miles 28 420
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Immunologic Defects in Laboratory Animals 1 (Paperback, Softcover reprint of the original 1st ed. 1981)
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Tiselius demonstrated that the immunologically active components of
immune sera migrated electrophoretically in the gamma globulin
region. His findings illuminated the classic observations of Jenner
regarding development of resistance to infection, and those of von
Pirquet, Pasteur, and Arthus regarding the transfer and specificity
of resistance. Conceptual integration of these observations
provided the impetus for the present modern era of immunology.
Subsequent to Tiselius's work, multiple, rapid advances have
occurred in the study of congenital and acquired immune deficiency
states in mice, chickens, and humans. These studies have readily
demonstrated that the immunologic ability of an organ ism to
protect itself from environmental influences is a prerequisite for
survival. Indeed, this necessity for protection from
microenvironmental influences has promoted the evolu tionary
development of immunologic diversification, namely, host dependence
upon a sophisticated, multifaceted network of cells and effector
mechanisms responsible for the clearance and neutralization of
toxins and potentially harmful pathogens. The obligate dependence
of animals upon the functional integrity of their immunologic
systems is illus trated by the ready invasion of ubiquitous
organisms when the host is in a state of immune defense
derangement. Nevertheless, derangements in immune function can
range from par tial to complete and can be compatible with
survival. The consequences of such derange ments run the gamut from
subclinical disease to inevitable mortality."
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