This second edition is fully updated throughout and covers the
emerging evidence that indicates that the Gadd45 family of proteins
plays a unique and critical role as sensors of stress, including
genotoxic, physiological, and oncogenic stress. It sheds
light on the complex cellular stress response, encompassing myriad
molecular pathways with a plethora of regulators and effectors. The
GADD45 stress response genes encode small (18 kd)
nuclear/cytoplasmic proteins. These genes are rapidly
induced by a wide variety of endogenous and exogenous stress
stimuli. Despite marked similarities, Gadd45 genes are regulated
differentially and exhibit functional diversity. Gadd45
proteins respond to physiological and oncogenic stress, and are
implicated in cell cycle arrest, DNA demethylation and repair,
apoptosis, cell survival, genomic stability, and inflammation. The
purpose of this book is to provide a comprehensive overview of the
unique global role that Gadd45 proteins play as stress sensors and
the molecular pathways involved.
General
Imprint: |
Springer Nature Switzerland AG
|
Country of origin: |
Switzerland |
Series: |
Advances in Experimental Medicine and Biology, 1360 |
Release date: |
May 2023 |
First published: |
2022 |
Editors: |
M. Raza Zaidi
• Dan A. Liebermann
|
Dimensions: |
254 x 178mm (L x W) |
Pages: |
153 |
Edition: |
2nd ed. 2022 |
ISBN-13: |
978-3-03-094806-1 |
Categories: |
Books
|
LSN: |
3-03-094806-4 |
Barcode: |
9783030948061 |
Is the information for this product incomplete, wrong or inappropriate?
Let us know about it.
Does this product have an incorrect or missing image?
Send us a new image.
Is this product missing categories?
Add more categories.
Review This Product
No reviews yet - be the first to create one!