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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Neurotransmitter Transporters - Structure, Function, and Regulation (Paperback, Softcover reprint of the original 2nd ed. 2002)
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Neurotransmitter Transporters - Structure, Function, and Regulation (Paperback, Softcover reprint of the original 2nd ed. 2002)
Series: Contemporary Neuroscience
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Neurotransmission is a multicomponent process. Transmitters,
released by neuronal activity, act on pre- and postsynaptic
receptors, and many books detail advances in the receptor field. In
addition, after their release from nerve endings, transmitters are
removed from the neuronal vicinity by uptake into neuronal or glial
cells by specific tra- porter proteins that have been studied
intensely over the last 30 years; this information is scattered
throughout numerous publishing vehicles. Therefore, the primary aim
of this second edition of N- rotransmitter Transporters: Structure,
Function, and Regulation is to offer a comprehensive picture of the
characterization of neurotransmitter transporters and their
biological roles. The transporter field has moved forward in
stages. In the first phase, progress came from the use of substrate
or blocker ligands selectively targeting transporters, the
application of model systems allowing the study of transmitter tra-
port shielded from storage, and the development of mathematical
models for describing transport phenomena. In the second phase,
roughly covering the last decade, advances in DNA techniques
allowed the cloning of numerous genes coding for different
transporter proteins. In the current, third stage, a wealth of
information is being accumulated in studies relating transporter
structure with function, experiments addressing regulation by
posttranslational transfor- tion, investigations into transport
modulation by trafficking processes and genomic influences,
characterization of channel properties of tra- porters by
electrophysiological approaches, and the creation of transgenic
animals under- or overexpressing a given transporter protein.
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