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Books > Medicine > Pre-clinical medicine: basic sciences > Physiology
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Recent Advances in Prolactin Research (Hardcover, 2015 ed.)
Loot Price: R2,957
Discovery Miles 29 570
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Recent Advances in Prolactin Research (Hardcover, 2015 ed.)
Series: Advances in Experimental Medicine and Biology, 846
Expected to ship within 10 - 15 working days
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Recent Advances in Prolactin Research summarizes the current
knowledge of prolactin (PRL), PRL receptor, PRL-dependent signaling
pathways, the role of PRL in oncogenesis and PRL crosstalk with
other oncogenic factors. The chapters are written by experts in
these fields and focus on identifying and reviewing timely
experimental findings that provide new insights into the expanding
role of PRL in the pathophysiology associated with a variety of
human conditions. Prolactin is a peptide hormone that is best known
for its role in lactation. Prolactin also has an influence on
hematopoiesis and angiogenesis, and is involved in the regulation
of blood clotting through several pathways. Although PRL was
discovered more than 80 years ago, the understanding of PRL
signaling and its relationship to various pathologies is still very
incomplete. PRL is not only a pituitary hormone with an important
role in reproduction, but PRL also acts as a cytokine, modulating a
wide variety of physiological processes. For example, data gathered
during the last decade have demonstrated that locally produced PRL
acts as the autocrine/paracrine factor and plays a contributory
role during breast oncogenesis. In fact, the scientific and
clinical communities have suggested that the manipulation of the
PRL axis may lead to the successful treatment of breast cancer.
However, recent work has demonstrated that the role of the PRL axis
is much more complex than first envisaged.
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