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Books > Medicine > Surgery > Orthopaedics & fractures
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Cartilage and Osteoarthritis (Hardcover, 2004 ed.)
Loot Price: R4,074
Discovery Miles 40 740
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Cartilage and Osteoarthritis (Hardcover, 2004 ed.)
Series: Methods in Molecular Medicine, 100
Expected to ship within 10 - 15 working days
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Osteoarthritis (OA), the most common form of arthritis, is
generally characterized by a slowly progressive degeneration of
articular cartilage, particularly in the weight-bearing joints. It
has a stronger prevalence in women, and its incidence increases
with age. OA is a major and growing health concern in developed
countries, owing to steadily increasing life expectancy and the
demand for better quality of life. Because of its chronic nature
and nonfatal outcome, OA affects the growing population of the
elderly over an increasing time span. Moreover, despite its
relatively benign character, OA is one of the most disabling
diseases; it is responsible for increasing financial and social
burdens in terms of medical treatments, forced inactivity, loss of
mobility, and dependence. Despite a growing awareness of OA as a
medical problem that has yet to reach its maximum impact on
society, there is a surprising absence of effective medical
treatments beyond pain control and surgery. So far, only
symptom-modifying drugs are available, while there remains a major
demand for disease-modifying treatments of proven clinical
efficacy. This demand will hopefully be met in the future by some
of the drugs that have been pressed into development and are now at
different stages of clinical investigation. Nevertheless, the
current lack of effective treatments reflects a still insufficient
knowledge of cartilage with respect to its metabolism, interactions
with other joint tissues, and causes and mechanisms (possibly of
very different nature) leading to failure of its turnover.
General
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