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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Mechanisms of Angiogenesis (Hardcover, 2005 ed.)
Loot Price: R4,410
Discovery Miles 44 100
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Mechanisms of Angiogenesis (Hardcover, 2005 ed.)
Series: Experientia Supplementum, 94
Expected to ship within 10 - 15 working days
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Is it advisable to go back from bedside to the bench? During the
last decade, few topics encountered such a broad interest in bio-
gy and medicine as angiogenesis. The amazing ability of the body to
restore blood flow by induction of blood vessel growth as part of
an adaptive process has alarmed physicians dealing with diseases in
which angiogenesis is either exaggerated (as in tumors) or too slow
(as in ischemic diseases of heart and brain). Not surprisingly,
pro- and antiangiogenic strategies have found their way into
clinical trials. For instance, for the USA, the NIH website in
early 2004 displayed 38 clinical studies involving either pro- or
antiangiogenic th- apies. Given the expected overwhelming wealth of
clinical data, the question may be asked whether further
exploration of biological mechanisms is required or whether results
from the bedside are instructive enough to proceed. This question
depends also on the progress of pro- and antiangiogenic clinical
trials. In the following, I give a short overview about some of the
progress that has been made in this field. Since Judah Folkman
proposed antiangiogenic tumor therapy thirty years ago, it has
become increasingly evident that agents which interfere with blood
vessel formation also block tumor progression. Accordingly,
antiangiogenic therapy has gained much attention as a potential
adjunct to conventional c- cer therapy.
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