Bacterial polysaccharides represent a diverse range of
macromolecules that include peptidoglycan, lipopolysaccharides,
capsules, and exopolysaccharides - compounds whose functions range
from structural cell-wall components (e.g. peptidoglycan) - and
important virulence factors (e.g. Poly-N-acetylglucosamine in S.
aureus) to permitting the bacterium to survive in harsh
environments (e.g. Pseudomonas aeruginosa in the human lung).
Polysaccharide biosynthesis is a tightly-regulated,
energy-intensive process. Understanding the subtle interplay
between the regulation and energy conservation, the polymer
modification and synthesis, and the external ecological functions
is a huge area of research. The potential benefits are enormous and
should enable, for example, the development of novel antibacterial
strategies (e.g. new antibiotics and vaccines) and the commercial
exploitation to develop novel applications. In this timely book,
experienced and authoritative experts review the most important
innovations in the research and biotechnological applications of
bacterial polysaccharides. The book takes an interdisciplinary view
that examines this fascinating subject area in detail from
molecular biology, genome-, transcriptome-, and proteome-wide
perspectives, and looks at the ecological aspects and systems
biology approaches. It provides a sound basis for future research
directions, including high efficiency applications of bacterial
polysaccharides in medicine, the food industry, and renewable
energy production. Topics include: peptidoglycan,
lipopolysaccharide, arabinogalactan, capsule gene expression in
Escherichia coli, immune response to polysaccharides,
polysaccharides from periodontopathic bacteria, role in dental
plaque, biofilms, levan, amylovoran, and much more.
General
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