Nearly 40% of new drug candidates exhibit low solubility in water,
which leads to poor oral bioavailability, high intra- and
inter-subject variability and lack of dose proportionality.
Modification of the physicochemical properties, such as salt
formation and particle size reduction of the compound may be one
approach to improve the dissolution rate of the drug. However,
these methods have their own limitations. In recent years, much
attention has focused on lipid based formulations to improve the
oral bioavailability of poorly water soluble drugs. In fact, the
most popular approach is the incorporation of the drug compound
into inert lipid vehicles such as oils, surfactant dispersions,
self-emulsifying formulations, emulsions and liposomes with
particular emphasis on self-microemulsifying drug delivery systems
(SMEDDS).
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