This book aims to provide a state-of-the-art summary of what is
currently known about brain glycogen metabolism, detailing the
recent advances in our understanding of why glycogen is so critical
for normal brain function. The role of glycogen in cellular
neurophysiology remains largely unclear and its specific
contribution to the energy demand of brain cells is still
elusive.Glycogen is the sole cerebral glucose reserve and is
emerging as a fundamental component of brain energy metabolism.
Pharmacological or genetic manipulation of glycogen metabolism in
the brain impairs memory formation and increases susceptibility to
epileptic seizures and cortical spreading depression. Glycogen is
also directly implicated in abnormal neuronal excitability and
mental retardation that characterize brain disorders like Lafora
disease and Pompe disease.
General
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