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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Cells, Aging, and Human Disease (Hardcover, New)
Loot Price: R3,288
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Cells, Aging, and Human Disease (Hardcover, New)
Expected to ship within 12 - 17 working days
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Cells, Aging, and Human Disease is the first book to explore aging
all the way from genes to clinical application, analyzing the
fundamental cellular changes which underlie human age-related
disease. With over 4,000 references, this text explores both the
fundamental processes of human aging and the tissue-by-tissue
pathology, detailing both breaking research and current
state-of-the-art clinical interventions in aging and age-related
disease.
Far from merely sharing a common onset late in the lifespan,
age-related diseases are linked by fundamental common
characteristics at the genetic and cellular levels. Emphasizing
human cell mechanisms, the first section presents and analyzes our
current knowledege of telomere biology and cell senescence. In
superb academic detail, the text brings the reader up to date on
telomere maintenance, telomerase dynamics, and current research on
cell senescence--and the general model--cell senescence as the
central component in human senescence and cancer. For each human
malignancy, the chapter reviews and analyzes all available data on
telomeres and telomerase, as well as summarizing current work on
their clinical application in both diagnosis and cancer therapy.
The second edition, oriented by organs and tissues, explores the
actual physiological impact of cell senescence and aging on
clinical disease. After a summary of the literature on early aging
syndromes--the progerias--the text reviews aging diseases
(Alzheimer's dementia, osteoarthritis, atherosclerosis, immune
aging, presbyopia, sarcopenia, etc.) in the context of the tissues
in which they occur. Each of the ten clinical chapters--skin,
cardiovascular system, bone and joints, hematopoetic and immune
systems, endocrine, CNS, renal, muscle, GI, and eyes--examines what
we know of their pathology, the role of cell sensescence, and
medical interventions, both current and potential.
General
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