Upstream processing refers to the production of proteins by cells
genetically engineered to contain the human gene which will express
the protein of interest. The demand for large quantities of
specific proteins is increasing the pressure to boost cell culture
productivity, and optimizing bioreactor output has become a primary
concern for most pharmaceutical companies. Each chapter in Cell
Culture and Upstream Processing is taken from presentations at the
highly acclaimed IBC conferences as well as meetings of the
European Society for Animal Cell Technology (ESACT) and Protein
Expression in Animal Cells (PEACe) and describes how to improve
yield and optimize the cell culture production process for
biopharmaceuticals, by focusing on safety, quality, economics and
operability and productivity issues. Cell Culture and Upstream
Processing will appeal to a wide scientific audience, both
professional practitioners of animal cell technology as well as
students of biochemical engineering or biotechnology in graduate or
high level undergraduate courses at university.
General
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