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Books > Medicine > Nursing & ancillary services > Biomedical engineering
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Anticipatory Ethics and The Use of CRISPR in Humans (Hardcover, 1st ed. 2022)
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Anticipatory Ethics and The Use of CRISPR in Humans (Hardcover, 1st ed. 2022)
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The future of gene editing in humans will involve the use of
CRISPR. How we think about the combination of the scientific,
ethical, and moral aspects of this technology is paramount to the
success or failure of CRISPR in humans. Unfortunately, the current
scientific discussion around CRISPR in humans has left ethics
trailing behind due to the rapid pace of innovation. New modes of
ethics and stakeholder participation are needed to keep pace with
rapid scientific advances and provide the necessary policy and
ethical frameworks necessary to help CRISPR flourish as an
important health care tool to treat human disease. This requires
intense interdisciplinary collaboration and discussion between
scientists and philosophers, policymakers and legal scholars, and
the public. Dr. Michael W. Nestor (a neuroscientist who actively
uses CRISPR in pre-clinical research) and Professor Richard Wilson
(a philosopher who focuses on anticipatory ethics) set out to
develop a new ethical approach considering the use of CRISPR in
human targeted therapies. The field of anticipatory ethics is
uniquely poised to tackle questions in fast-evolving technical
areas where the pace of innovation outstrips traditional
philosophical approaches. Furthermore, because of its
"anticipatory" nature, this type of analysis provides the
opportunity to look ahead and into the future concerning potential
uses of CRISPR in humans, uses that are not currently possible.
Nestor and Wilson collaborate both scientifically and
philosophically in this book to forecast potential outcomes as the
scientific and medical community goes beyond using CRISPR to
correct genes that underlie diseases where a single gene is
involved. Instead, Nestor and Wilson envision CRISPR in complex,
multigenic disorders with a specific focus on the use of CRISPR to
edit genes involved in mental traits like IQ or other cognitive
characteristics. They argue that the use of CRISPR to modify genes
that are potentially important for mental traits represents a
particular category for special consideration from scientists,
policymakers, the public, and other stakeholders. Nestor and Wilson
explain why using CRISPR to alter mental states is very different
from treating a disease like cancer by combining the latest
scientific advancements with anticipatory ethics and philosophical
phenomenology. Their analysis considers the role that mental states
play in personhood and the lived experience-as genes that can
change mental/cognitive attributes like IQ have wide-ranging
effects on the lived experience in ways that are categorically
different from other attributes. This book was written to set a
non-exhaustive framework for shared understanding and discussion
across disciplines and appeal to scientists and non-scientists
alike. This appeal is made inclusively, inviting all stakeholders
to engage in active dialogue about the appropriate context for
using CRISPR and other gene-editing technologies in humans. It
provides policy analysis and recommendations for assuring the most
inclusive, equitable, and ethically sound use of CRISPR in humans,
concerning its positive potential to treat mental conditions like
depression, schizophrenia, Alzheimer's disease, autism, and the
potential to induce other cognitive enhancements.
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