The fifth edition includes new sections on the use of adverse
outcome pathways, how climate change changes how we think about
toxicology, and a new chapter on contaminants of emerging concern.
Additional information is provided on the derivation of
exposure-response curves to describe toxicity and they are compared
to the use of hypothesis testing. The text is unified around the
theme of describing the entire cause-effect pathway from the
importance of chemical structure in determining exposure and
interaction with receptors to the use of complex systems and
hierarchical patch dynamic theory to describe effects to
landscapes.
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