Understanding the genetic architecture underlying complex multigene
disorders is one of the major goals of human genetics in the
upcoming decades. Advances in whole genome sequencing and the
success of high throughput functional genomics allow supplementing
conventional reductionist biology with systems-level approaches to
human heredity and health as systems of interacting genetic,
epigenetic, and environmental factors. This integrative approach
holds the promise of unveiling yet unexplored levels of molecular
organization and biological complexity. It may also hold the key to
deciphering the multigene patterns of disease inheritance.
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