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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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SH Domains - Structure, Mechanisms and Applications (Hardcover, 1st ed. 2015)
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SH Domains - Structure, Mechanisms and Applications (Hardcover, 1st ed. 2015)
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This book covers structure, function, and important roles of the SH
domains, structure-function relationships, the versatile nature of
their action, mechanisms of aggregation, specificity of
interactions, impact of mutations on protein functional
dysregulation, and cell signaling. Their involvement in various
cellular processes such as migration, invasiveness, actin
reorganization, shaping spines, determination of the morphology
assembly of fibrils, and mechanotransduction makes these molecules
attractive drug targets. Substrates, inhibitors and activators of
PTKs present a wide variety of therapeutic agents in the context of
delivering treatments for numerous pathologies. The new emerging
field of stem cell therapies and design of biomaterials for
treatments relies on the directed regulation of stem cell growth,
differentiation and morphology, as well as the production of
biomimetic scaffolds that respond to programmed signals. Advances
in deciphering the mechanisms of action of these important
molecules will lead to the implementation and success of their
vital applications.
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