Using 21st Century Science to Improve Risk-Related Evaluations (Paperback)

Over the last decade, several large-scale United States and international programs have been initiated to incorporate advances in molecular and cellular biology, -omics technologies, analytical methods, bioinformatics, and computational tools and methods into the field of toxicology. Similar efforts are being pursued in the field of exposure science with the goals of obtaining more accurate and complete exposure data on individuals and populations for thousands of chemicals over the lifespan; predicting exposures from use data and chemical-property information; and translating exposures between test systems and humans. Using 21st Century Science to Improve Risk-Related Evaluations makes recommendations for integrating new scientific approaches into risk-based evaluations. This study considers the scientific advances that have occurred following the publication of the NRC reports Toxicity Testing in the 21st Century: A Vision and a Strategy and Exposure Science in the 21st Century: A Vision and a Strategy. Given the various ongoing lines of investigation and new data streams that have emerged, this publication proposes how best to integrate and use the emerging results in evaluating chemical risk. Using 21st Century Science to Improve Risk-Related Evaluations considers whether a new paradigm is needed for data validation, how to integrate the divergent data streams, how uncertainty might need to be characterized, and how best to communicate the new approaches so that they are understandable to various stakeholders. Table of Contents Front Matter Summary 1 Introduction 2 Advances in Exposure Science 3 Advances in Toxicology 4 Advances in Epidemiology 5 A New Direction for Risk Assessment and Applications of 21st Century Science 6 Model and Assay Validation and Acceptance 7 Interpretation and Integration of Data and Evidence for Risk-Based Decision-Making Appendix A: Biographical Information on the Committee on Incorporating 21st Century Science into Risk-Based Evaluations Appendix B: Case Studies on Chemical Assessments Appendix C: Case Studies on Site-Specific Assessments Appendix D: Case Study on Assessment of New Chemistries Appendix E: A Bayesian Example: Predicting DoseResponse Relationships from High-Throughput Data and Chemical Structure

General

Imprint:	National Academies Press
Country of origin:	United States
Release date:	March 2017
Authors:	National Academies of Sciences, Engineering, and Medicine • Division on Earth and Life Studies • Board on Environmental Studies and Toxicology • Committee on Incorporating 21st Century Science into Risk-Based Evaluations
Dimensions:	279 x 216mm (L x W)
Format:	Paperback
Pages:	200
ISBN-13:	978-0-309-45348-6
Categories:	Books > Earth & environment > The environment > Applied ecology > General Books > Earth & environment > The environment > Pollution & threats to the environment > General
LSN:	0-309-45348-8
Barcode:	9780309453486

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