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From Molecular Insights to Patient Stratification for Neurological and Psychiatric Disorders - Proceedings of a Workshop (Paperback)
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From Molecular Insights to Patient Stratification for Neurological and Psychiatric Disorders - Proceedings of a Workshop (Paperback)
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While significant progress has been seen in fields such as
cardiovascular medicine and cancer in improving patient
stratification and developing targeted drugs based on genetic
findings, progress continues to lag for neuropsychiatric disorders.
To address this issue, the National Academies of Sciences,
Engineering, and Medicine's Forum on Neuroscience and Nervous
System Disorders convened a workshop in October 2021. The workshop
brought together government, philanthropic foundations, and
disease-focused non--profit organizations to discuss new genetic
and neuroscience technologies and explore how they can be used to
elucidate disease mechanisms and to advance the development of
biomarkers and targeted therapies for people with neurological and
psychiatric disorders. This Proceedings of a Workshop summarizes
the presentations and discussions of the workshop. Table of
Contents Front Matter 1 Introduction and Background 2 Leveraging
New Genetic and Neuroscience Technologies to Advance Therapeutic
Development: Opportunities and Challenges 3 Increasing Ancestral
Diversity to Enable Precision Medicine for Neurological and
Psychiatric Disorders 4 Leveraging New Methodologies to Interpret
Genetic Data in Neurological and Psychiatric Disorders 5
Identifying and Validating Molecular Pathways Using New
Technologies for Human Biology 6 Enabling Patient Stratification
through Deep Phenotyping and Biomarker Discovery 7 Potential Next
Steps: Shifting the Trajectory of Treatment Development for
Neurological and Psychiatric Disorders Appendix A: References
Appendix B: Workshop Agenda
General
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