Biomarkers of Neuroinflammation - Proceedings of a Workshop (Paperback)

Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics. To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop. Table of Contents Front Matter 1 Introduction and Overview 2 Biomarkers of Neuroinflammation: Challenges and Potential Opportunities 3 State of the Science of Neuroinflammation in Central Nervous System Disorders 4 Neuroinflammation in Disease 5 Neuroimaging Biomarkers: Current Initiatives and Opportunities 6 Cerebrospinal Fluid and Other Fluid Biomarkers: Current Initiatives and Opportunities 7 Potential Mechanisms for Moving Forward Appendix A References Appendix B Workshop Agenda Appendix C Registered Attendees

General

Imprint:	National Academies Press
Country of origin:	United States
Release date:	March 2018
First published:	2018
Authors:	National Academies of Sciences, Engineering, and Medicine • Health and Medicine Division • Board on Health Sciences Policy • Forum on Neuroscience and Nervous System Disorders
Editors:	Sheena M. Posey Norris • Noam I. Keren • Lisa Bain
Dimensions:	229 x 152mm (L x W)
Format:	Paperback
Pages:	90
ISBN-13:	978-0-309-46365-2
Categories:	Books > Medicine > General
LSN:	0-309-46365-3
Barcode:	9780309463652

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