Large temperate rivers around the world have been historically
affected by human activities and face an uncertain future in which
water quality may be further threatened by climate change, urban
development, agriculture, exotic species, recreation, and
transportation uses (Meybeck and Helmer 1989; Zhang et al. 1999).
In addition, large rivers can transfer water quality pollutants
from land to sea, such as agricultural nitrogen in the Mississippi
River causing hypoxia in the Gulf of Mexico (Burkart and James
1999).
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