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Technologies to Enable Autonomous Detection for BioWatch - Ensuring Timely and Accurate Information for Public Health Officials: Workshop Summary (Paperback, New)
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Technologies to Enable Autonomous Detection for BioWatch - Ensuring Timely and Accurate Information for Public Health Officials: Workshop Summary (Paperback, New)
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The BioWatch program, funded and overseen by the Department of
Homeland Security (DHS), has three main elements-sampling,
analysis, and response-each coordinated by different agencies. The
Environmental Protection Agency maintains the sampling component,
the sensors that collect airborne particles. The Centers for
Disease Control and Prevention coordinates analysis and laboratory
testing of the samples, though testing is actually carried out in
state and local public health laboratories. Local jurisdictions are
responsible for the public health response to positive findings.
The Federal Bureau of Investigation is designated as the lead
agency for the law enforcement response if a bioterrorism event is
detected. In 2003 DHS deployed the first generation of BioWatch air
samplers. The current version of this technology, referred to as
Generation 2.0, requires daily manual collection and testing of air
filters from each monitor. DHS has also considered newer automated
technologies (Generation 2.5 and Generation 3.0) which have the
potential to produce results more quickly, at a lower cost, and for
a greater number of threat agents. Technologies to Enable
Autonomous Detection for BioWatch is the summary of a workshop
hosted jointly by the Institute of Medicine and the National
Research Council in June 2013 to explore alternative cost-effective
systems that would meet the requirements for a BioWatch Generation
3.0 autonomous detection system, or autonomous detector, for
aerosolized agents . The workshop discussions and presentations
focused on examination of the use of four classes of
technologies-nucleic acid signatures, protein signatures, genomic
sequencing, and mass spectrometry-that could reach Technology
Readiness Level (TRL) 6-plus in which the technology has been
validated and is ready to be tested in a relevant environment over
three different tiers of temporal timeframes: those technologies
that could be TRL 6-plus ready as part of an integrated system by
2016, those that are likely to be ready in the period 2016 to 2020,
and those are not likely to be ready until after 2020. Technologies
to Enable Autonomous Detection for BioWatch discusses the history
of the BioWatch program, the role of public health officials and
laboratorians in the interpretation of BioWatch data and the
information that is needed from a system for effective decision
making, and the current state of the art of four families of
technology for the BioWatch program. This report explores how the
technologies discussed might be strategically combined or deployed
to optimize their contributions to an effective environmental
detection capability. Table of Contents Front Matter 1 Introduction
2 Overview of the BioWatch Program 3 Public Health's Perspective on
the Role of BioWatch in the Decision-Making Process 4 Potential
Technologies for the BioWatch Program 5 Final Thoughts Appendix A:
References Appendix B: Biographical Sketches of Workshop
Participants Appendix C: Workshop Agenda Appendix D: Registered
Attendees Appendix E: Technology Readiness Levels in the Department
of Defense Appendix F: White Paper 1: The BioWatch Program: What
Information Is Needed to Inform Decision Making? Appendix G: White
Paper 2: Nucleic-Acid Signatures at Three Levels of Readiness for
BioWatch Appendix H: White Paper 3: State of the Art for Autonomous
Detection Systems Using Immunoassays and Protein Signatures
Appendix I: White Paper 4: State of the Art for Autonomous
Detection Systems Using Genomic Sequencing Appendix J: White Paper
5: State of the Art for Autonomous Detection Systems Using Mass
Spectrometry
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