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Acetylsalicylic Acid (Aspirin) (Paperback)
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Acetylsalicylic Acid (Aspirin) (Paperback)
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Aspirin (acetylsalicylic acid, ASA) has been used as one of the
most famous, cheap, easily available and widely used Non Steroidal
Anti Inflammatory Drug (NSAID). Aspirin is used in versatile
purpose such as, anti-inflammatory (in joint diseases),
anti-platelets (in cardiovascular disease), analgesic and
antipyretic. The aim of present investigation is to study the
effect of oral administration of drug acetylsalicylic acid (ASA,
aspirin) on female albino rat, Rattus norvegicus. The female rats
(n=24) were allocated into 2 groups as control (n=12) and treated
(n=12). The treated rats were given oral dose of aspirin 100 mg/ kg
body weight for 15 days (n=6) and 30 days (n=6). The present
investigation results suggest that the high doses of ASA, induced
histopathological changes in liver, kidney and reproductive organs
directly or indirectly through modulation of certain biochemical
and enzymological activities. These effects are dose and duration
dependent.
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