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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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Alpha-fetoprotein - Functions & Clinical Application (Hardcover)
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Alpha-fetoprotein - Functions & Clinical Application (Hardcover)
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Alpha-fetoprotein (AFP) has many applications across various
disciplines. This oncofetal protein is routinely used by clinicians
for antenatal testing as well for the screening and treatment
monitoring of certain malignances. Innovative research using AFP
has also been very promising. Recent developments include the use
of AFP or its recombinant fragments for drug delivery to cancer
cells, as well as for the engineering of cancer vaccines and T cell
immunotherapies. The anti-estrogenic potential of AFP has also been
utilised to develop drugs directed against estrogen receptor
positive malignancies. This book is divided into five sections. In
Section One, the history of AFP is recollected, and the role of AFP
in normal and pathological conditions is explored. Section Two and
Three focus on the utility of AFP during pregnancy. In Section Two,
the use of routine maternal serum AFP screening for detection of
chromosomal aneuploidies and neural tube defects in normal
pregnancies and pregnancies with pre-existing disease is discussed;
the potential use of AFP for the detection of preeclampsia is also
reviewed. Section Three explores the pathogenesis and data linking
unexplained elevations of AFP to adverse obstetrical outcomes.
Section Four presents chapters that discuss AFP ligand binding,
receptor targeting, and drug delivery strategies. Finally, Section
Five serves to explain the regulatory roles of AFP, its use in
immunotherapy, and in the development of cancer vaccines. The aim
of this book is to bring together some of the great research and
clinical insights that currently surround AFP. The target audiences
for this book are basic science researchers as well as clinicians.
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