Olesja Rissling analyzes the potential interaction of mycophenolic
acid (MPA) and pantoprazole. MPA is used as an immunosuppressive
drug to prevent acute organ rejections after organ transplantation.
Pantoprazole, known to interact with the bioavailability of drugs,
is used to prevent upper gastrointestinal disorders. The author
performed a clinical pharmacokinetic study in renal transplant
patients to evaluate a potential interaction of MPA and
pantoprazole. The bioavailability and the maximum concentration of
MPA were determined with or without pantoprazole intake. An
influence on the immunosuppressive effect was evaluated by
measuring the target enzyme activity. Overall, no significant
change in the bioavailability or the maximum concentration was
found. Similar results were obtained for the target enzyme activity
after pantoprazole intake with MPA. The results suggest that the
interaction of pantoprazole with MPA does not compromise the
immunosuppressive effect to a clinically meaningful extent.
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